Longitudinal profiles of immunoglobulin G antibodies against severe acute respiratory syndrome coronavirus components and neutralizing activities in recovered patients
Identifieur interne : 002366 ( Main/Exploration ); précédent : 002365; suivant : 002367Longitudinal profiles of immunoglobulin G antibodies against severe acute respiratory syndrome coronavirus components and neutralizing activities in recovered patients
Auteurs : LIFENG LIU [République populaire de Chine] ; JING XIE [République populaire de Chine] ; JIANPIN SUN [République populaire de Chine] ; YANG HAN [République populaire de Chine] ; CHAO ZHANG [République populaire de Chine] ; HONGWEI FAN [République populaire de Chine] ; ZHENGYIN LIU [République populaire de Chine] ; ZHIFENG QIU [République populaire de Chine] ; YUXIAN HE [République populaire de Chine] ; TAISHENG LI [République populaire de Chine]Source :
- Scandinavian journal of infectious diseases [ 0036-5548 ] ; 2011.
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- topic : Homme.
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Abstract
Background: Immunological memory is the basis for vaccination. Currently, the longitudinal profiles of antibody responses in recovered severe acute respiratory syndrome (SARS) patients have not been fully characterized. Methods: In this study we sequentially followed up 19 recovered SARS patients over a 3-y period in order to characterize the dynamic changes in antibody responses against viral components in detail. In addition, 4 blood samples were obtained at month 60. Results: We found that immunoglobulin G (IgG) antibodies and their neutralizing activities decreased throughout the entire phase of the study. For IgG antibodies in the 3rd y, the positive rate of whole-virus-specific antibodies was 42%, which was tested with commercial kits at 1/10 dilution of the sera. In comparison, the positive rate of spike (S) protein-specific antibodies was 100%, which was tested by spike protein-based ELISA at 1/100 dilution; 4 samples at month 60 were included. The average optical density (OD) reading of nucleocapsid (N) protein-specific antibodies fell dramatically between month 3 and month 12, and it decreased gradually at low levels that were a little higher than the cut-off value from month 12. For neutralizing antibodies, neutralizing activity was detectable in 89% of recovered patients in the 3rd y. S protein-specific IgG levels (r = 0.717) correlated better with neutralizing activity than SARS coronavirus-specific IgG levels (r = 0.571). Conclusions: These systematic findings provide valuable information on natural humoral memory responses, and the data will be helpful for understanding the pathogenesis of SARS coronavirus infection and for the rational design of vaccines.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Longitudinal profiles of immunoglobulin G antibodies against severe acute respiratory syndrome coronavirus components and neutralizing activities in recovered patients</title><author><name sortKey="Lifeng Liu" sort="Lifeng Liu" uniqKey="Lifeng Liu" last="Lifeng Liu">LIFENG LIU</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Infectious Diseases, Peking Union Medical College Hospital</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Jing Xie" sort="Jing Xie" uniqKey="Jing Xie" last="Jing Xie">JING XIE</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Infectious Diseases, Peking Union Medical College 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Union Medical College Hospital</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zhengyin Liu" sort="Zhengyin Liu" uniqKey="Zhengyin Liu" last="Zhengyin Liu">ZHENGYIN LIU</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Infectious Diseases, Peking Union Medical College Hospital</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zhifeng Qiu" sort="Zhifeng Qiu" uniqKey="Zhifeng Qiu" last="Zhifeng Qiu">ZHIFENG QIU</name><affiliation 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LI</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Infectious Diseases, Peking Union Medical College Hospital</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">11-0301179</idno><date when="2011">2011</date><idno type="stanalyst">PASCAL 11-0301179 INIST</idno><idno type="RBID">Pascal:11-0301179</idno><idno type="wicri:Area/PascalFrancis/Corpus">000102</idno><idno type="wicri:Area/PascalFrancis/Curation">000886</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000087</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000087</idno><idno type="wicri:doubleKey">0036-5548:2011:Lifeng Liu:longitudinal:profiles:of</idno><idno type="wicri:Area/Main/Merge">002394</idno><idno type="wicri:Area/Main/Curation">002366</idno><idno type="wicri:Area/Main/Exploration">002366</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Longitudinal profiles of immunoglobulin G antibodies against severe acute respiratory syndrome coronavirus components and neutralizing activities in recovered patients</title><author><name sortKey="Lifeng Liu" sort="Lifeng Liu" uniqKey="Lifeng Liu" last="Lifeng Liu">LIFENG LIU</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Infectious Diseases, Peking Union Medical College Hospital</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Jing Xie" sort="Jing Xie" uniqKey="Jing Xie" last="Jing Xie">JING XIE</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Infectious Diseases, Peking Union Medical College Hospital</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Jianpin Sun" sort="Jianpin Sun" uniqKey="Jianpin Sun" last="Jianpin Sun">JIANPIN SUN</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute of Pathogen Biology, Peking Union Medical College and Chinese Academy of Medical Sciences</s1><s2>Beijing</s2><s3>CHN</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Yang Han" sort="Yang Han" uniqKey="Yang Han" last="Yang Han">YANG HAN</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Infectious Diseases, Peking Union Medical College Hospital</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Chao Zhang" sort="Chao Zhang" uniqKey="Chao Zhang" last="Chao Zhang">CHAO ZHANG</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute of Pathogen Biology, Peking Union Medical College and Chinese Academy of Medical Sciences</s1><s2>Beijing</s2><s3>CHN</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Hongwei Fan" sort="Hongwei Fan" uniqKey="Hongwei Fan" last="Hongwei Fan">HONGWEI FAN</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Infectious Diseases, Peking Union Medical College Hospital</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zhengyin Liu" sort="Zhengyin Liu" uniqKey="Zhengyin Liu" last="Zhengyin Liu">ZHENGYIN LIU</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Infectious Diseases, Peking Union Medical College Hospital</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zhifeng Qiu" sort="Zhifeng Qiu" uniqKey="Zhifeng Qiu" last="Zhifeng Qiu">ZHIFENG QIU</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Infectious Diseases, Peking Union Medical College Hospital</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Yuxian He" sort="Yuxian He" uniqKey="Yuxian He" last="Yuxian He">YUXIAN HE</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute of Pathogen Biology, Peking Union Medical College and Chinese Academy of Medical Sciences</s1><s2>Beijing</s2><s3>CHN</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Taisheng Li" sort="Taisheng Li" uniqKey="Taisheng Li" last="Taisheng Li">TAISHENG LI</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Infectious Diseases, Peking Union Medical College Hospital</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Scandinavian journal of infectious diseases</title><title level="j" type="abbreviated">Scand. j. infect. dis.</title><idno type="ISSN">0036-5548</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Scandinavian journal of infectious diseases</title><title level="j" type="abbreviated">Scand. j. infect. dis.</title><idno type="ISSN">0036-5548</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibody</term><term>Coronavirus</term><term>Human</term><term>Immunoglobulins</term><term>Microbiology</term><term>Severe acute respiratory syndrome</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term><term>Immunoglobuline</term><term>Anticorps</term><term>Coronavirus</term><term>Homme</term><term>Microbiologie</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Immunological memory is the basis for vaccination. Currently, the longitudinal profiles of antibody responses in recovered severe acute respiratory syndrome (SARS) patients have not been fully characterized. Methods: In this study we sequentially followed up 19 recovered SARS patients over a 3-y period in order to characterize the dynamic changes in antibody responses against viral components in detail. In addition, 4 blood samples were obtained at month 60. Results: We found that immunoglobulin G (IgG) antibodies and their neutralizing activities decreased throughout the entire phase of the study. For IgG antibodies in the 3rd y, the positive rate of whole-virus-specific antibodies was 42%, which was tested with commercial kits at 1/10 dilution of the sera. In comparison, the positive rate of spike (S) protein-specific antibodies was 100%, which was tested by spike protein-based ELISA at 1/100 dilution; 4 samples at month 60 were included. The average optical density (OD) reading of nucleocapsid (N) protein-specific antibodies fell dramatically between month 3 and month 12, and it decreased gradually at low levels that were a little higher than the cut-off value from month 12. For neutralizing antibodies, neutralizing activity was detectable in 89% of recovered patients in the 3rd y. S protein-specific IgG levels (r = 0.717) correlated better with neutralizing activity than SARS coronavirus-specific IgG levels (r = 0.571). Conclusions: These systematic findings provide valuable information on natural humoral memory responses, and the data will be helpful for understanding the pathogenesis of SARS coronavirus infection and for the rational design of vaccines.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Lifeng Liu" sort="Lifeng Liu" uniqKey="Lifeng Liu" last="Lifeng Liu">LIFENG LIU</name></noRegion><name sortKey="Chao Zhang" sort="Chao Zhang" uniqKey="Chao Zhang" last="Chao Zhang">CHAO ZHANG</name><name sortKey="Hongwei Fan" sort="Hongwei Fan" uniqKey="Hongwei Fan" last="Hongwei Fan">HONGWEI FAN</name><name sortKey="Jianpin Sun" sort="Jianpin Sun" uniqKey="Jianpin Sun" last="Jianpin Sun">JIANPIN SUN</name><name sortKey="Jing Xie" sort="Jing Xie" uniqKey="Jing Xie" last="Jing Xie">JING XIE</name><name sortKey="Taisheng Li" sort="Taisheng Li" uniqKey="Taisheng Li" last="Taisheng Li">TAISHENG LI</name><name sortKey="Yang Han" sort="Yang Han" uniqKey="Yang Han" last="Yang Han">YANG HAN</name><name sortKey="Yuxian He" sort="Yuxian He" uniqKey="Yuxian He" last="Yuxian He">YUXIAN HE</name><name sortKey="Zhengyin Liu" sort="Zhengyin Liu" uniqKey="Zhengyin Liu" last="Zhengyin Liu">ZHENGYIN LIU</name><name sortKey="Zhifeng Qiu" sort="Zhifeng Qiu" uniqKey="Zhifeng Qiu" last="Zhifeng Qiu">ZHIFENG QIU</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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